Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale When using DIA-NN for the analysis of post-translation modifications (PTMs), such as phosphorylation or ubiquitination, please also cite (it's recommended to use the latest version - DIA-NN 1.8.1)ĭIA-NN: neural networks and interference correctionĮnable deep proteome coverage in high throughput Scalability and speed: up to 1000 mass spec runs processed per hour.Powerful tuning options to enable unconventional experiments.Ease of use: high degree of automation, an analysis can be set up in several mouse clicks, no bioinformatics expertise required.Reproducibility promoted by thorough recording of all analysis steps.Robustness achieved via flexible modelling of the data and automatic parameter selection.Reliability achieved via stringent statistical control.In 2018, DIA-NN opened a new chapter in proteomics, introducing a number of algorithms which enabled reliable, robust and quantitatively accurate large-scale experiments using high-throughput methods.ĭIA-NN is built on the following principles: DIA-NN - a universal software for data-independent acquisition (DIA) proteomics data processing by Demichev, Ralser and Lilley labs.
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